Diane Mathis

Diane Mathis is a Professor of Medicine at Harvard Medical School and a Senior Investigator at Joslin Diabetes Center, and an Associate Member at the Broad Institute. Her laboratory works in the fields of T-cell differentiation and autoimmunity, with a special emphasis on exploiting the most advanced transgenic and gene-targeting technologies to engineer new mouse models. Her studies on T cell differentiation focus on the selection of the T-cell repertoire, in particular the cellular and molecular mechanisms of positive and negative selection and lineage commitment. Her work on autoimmunity explores the immunological mechanisms of diabetes, rheumatoid arthritis and autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) using modern genetic and genomic approaches in both human patients and mouse models, and computational and bioinformatics strategies.

Learn more about research in the Mathis laboratory here.