John L. Rinn

John L. Rinn is an assistant professor of pathology at Harvard Medical School and Beth Israel Deaconess Medical Center and an associate member of the Broad Institute. His research aims to understand the role of large non-coding RNA in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in cancer. By exploiting multiple high-throughput genomic technologies his group is actively discovering and functionally characterizing an abundance of these mysterious molecules throughout the human genome. This work has revealed the ability of large non-coding RNAs to act in trans to silence large genomic regions via association with polycomb group complexes that could be further developed as novel cancer therapeutics that target and silence overactive oncogenes in cancer..

Learn more about research in the Rinn laboratory here.