Lewis Cantley

Lewis Cantley is a professor of systems biology at Harvard Medical School, the chief of the division of signal transduction in the department of medicine at Beth Israel Hospital and an associate member at the Broad Institute. His laboratory seeks to understand the biochemical pathways that regulate normal mammalian cell growth and the defects that cause cell transformation. More than 10 years ago, his laboratory discovered Phosphoinositide 3-Kinase (PI3K) and linked this pathway to insulin and growth factor signaling in normal cells and to cell growth and survival pathways in tumor cells. They have subsequently used peptide libraries and other biochemical approaches to elucidate the signaling pathways upstream and downstream of PI3K. In addition, they have generated mice deficient in genes for PI3K family members to understand the in vivo roles for this pathway.

Learn more about research in the Cantley laboratory here.