Tyler Jacks

Tyler Jacks is the David H. Koch professor of biology at MIT, the director of the MIT Center for Cancer Research, an investigator at the Howard Hughes Medical Institute and an associate member at the Broad Institute. His laboratory studies the genetic events that contribute to the development of cancer, with a particular focus on a series of mouse strains that are engineered to carry mutations in genes known to be involved in human cancers. Using conventional and conditional loss-of-function and gain-of-function mutations in various tumor suppressor genes as well as the K-ras oncogene, his group has constructed mouse models of lung cancer, astrocytoma, endometroid ovarian cancer, retinoblastoma, and tumors of the peripheral nervous system. His work also focuses on the effects of these mutations on normal embryonic development, using cells derived from mutant animals to study gene function in cell culture models.

Learn more about research in the Jacks laboratory here.