Home > Data > Genomes > Histoplasma capsulatum Database

Histoplasma capsulatum Database

Histoplasma capsulatum is the most common cause of fungal respiratory infections (histoplasmosis) in the world. While most infections are mild, 10% of cases result in life-threatening complications such as inflammation of the pericardium and fibrosis of major blood vessels (Durkin, Kohler et al. 2001). In addition, some African H. capsulatum isolates cause a distinct disease, African histoplasmosis, that is characterized by cutaneous and subcutaneous lesions in the bone (Jones and Goodwin., 1981). Once infected, a latent infection may be reactivated. Histoplasma poses a particular threat to the elderly and to immunocompromised patients (Rachid, Rezende et al. 2003). The comparative Histoplasma capsulatum project is funded by NIAID through the "Comparative Genomics of Coccidioides and other Pathogenic Dimorphic Fungi" whitepaper. This project aims to examine diversity between Histoplasma capsulatum strains and determine the common and unique features among the larger group of dimorphic fungal pathogens.

Tools BLAST Search: Find similarities to other sequences Feature Search: Search and view annotated features on the sequence Browse Regions: Retrieve DNA, find clones, and graphically view sequence regions Gene Index: Find genes by a variety of methods Genome Statistics:View basic statistics about genome size, gene density, etc Download Data: Download sequence, genes, markers, and other genome data Information Contact Us:Addresses for contacting the Broad Institute

Citations Rachid, A., L.S. Rezende et al. (2003). A case study of disseminated histoplasmosis linked to common variable immunodeficiency. Braz J Infect Dis. 7(4):268-272. Durkin M, Kohler S, Schnizlein-Bick C, LeMonte A, Connolly P, Goldberg J, Garringer T, Wheat LJ. (2001) Chronic infection and reactivation in a pulmonary challenge model of histoplasmosis. J Infect Dis. 183(12):1822-4. Kasuga T, White TJ, Koenig G, McEwen J, Restrepo A, Castaneda E, Da Silva Lacaz C, Heins-Vaccari EM, De Freitas RS, Zancope-Oliveira RM, Qin Z, Negroni R, Carter DA, Mikami Y, Tamura M, Taylor ML, Miller GF, Poonwan N, Taylor JW.(2003) Phylogeography of the fungal pathogen Histoplasma capsulatum. Mol Ecol. 12(12):3383-401. Jones RC, and Goodwin. RA Jr., (1981). Histoplasmosis of bone. Am J Med. 1981 Apr;70(4):864-6.