Paracoccidioides brasiliensis Database

Paracoccidioides brasiliensis Pb01

Paracoccidioides brasiliensis is the causal agent of paracoccidioidomycosis (PCM), one of the most important human systemic mycosis in Latin America. P. brasiliensis is a soil fungus that undergoes a dimorphic switch following host inhalation, due to increased temperature. It is estimated that about 10 million people are infected in South America. The annual incidence rate in Brazil is 10-30 infections per million inhabitants, and the mean mortality rate is 1.4 per million per year. The comparative Paracoccidioides project is funded by NIAID through the "Comparative Genomics of Coccidioides and other Pathogenic Dimorphic Fungi" whitepaper. This project aims to examine diversity between three Paracoccidioides strains and determine the common and unique features among the larger group of dimorphic fungal pathogens.

Tools

BLAST Search: Find similarities to other sequences

Feature Search: Search and view annotated features on the sequence

Browse Regions: Retrieve DNA, find clones, and graphically view sequence regions

Gene Index: Find genes by a variety of methods

Genome Statistics:View basic statistics about genome size, gene density, etc

Download Data: Download sequence, genes, markers, and other genome data

Information

Contact Us:Addresses for contacting the Broad Institute

Citations

  • Restrepo et al. The habitat of Paracoccidioides brasiliensis: how far from solving the riddle? Med Mycol. 2001
  • San-Blas G, Nino-Vega G: Paracoccidioides brasiliensis: virulence and host response. In Fungal pathogenesis: principles and clinical applications 1st edition. Edited by: Cihlar RL, Calderone RA. New York: Marcel Dekker, Inc; 2001:205-226.
  • Rooney PJ, Klein BS: Linking fungal morphogenesis with virulence. Cell Microbiol 2002, 4:127-37.
  • Brummer, E., Castaneda, E., Restrepo, A., 1993. Paracoccidioidomycosis: an update. Clin Microbiol Rev. 6, 89-117.