Cores
Core B: Library Synthesis, Formatting, and Creation
The library synthesis, library formatting, and
compound management core is the central organization that coordinates
and balances the chemistry needs of the four CMLD projects.
The reaction/library development section sets up
and maintains the custom-designed automated
reaction station. The station is used to execute both
solution-phase reactions and solid-phase reactions under inert
atmosphere in a high-throughput format.
The core facility contains state-of-the-art analytical
instruments and robotics, providing central analytical and
library formatting support for all CMLD projects, as well as
providing the supply of solid supports for all library realization
projects.
Once a library has been generated by one of the CMLD
projects, it is arrayed into an appropriate format by the
core staff before being released for biological screening. The
core is responsible for storing libraries created by all four
CMLD projects, and coordinates the distribution of chemical libraries
to various screening activities across the organization.
The core interacts with the CMLD
Cheminformatics Core to correlate the storage of compounds
with information regarding their synthesis, calculated molecular
descriptors, and biological activity.
Personnel
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