Broad Institute Chemical Biology Program

Compound Libraries

Important information about BCB DOS libraries:
The structure of the compound in each well must be decoded before cherry pick requests for DOS compounds can be filled.

Libraries Available for Screening

  • BDA1 (Bi- and Di-Aryl) (2,112 wells)
  • DHPC1 (Dihydropyrancarboxamide) (6,504 wells)
  • DHPC3 (Dihydropyrancarboxamide) (6,232 wells)
  • DHPC4 - Eg5 Focused (Dihydropyrancarboxamide) (135 wells)
  • DHPC5 - ATR Focused (Dihydropyrancarboxamide) (160 wells)
  • THOX1 (Tetrahydrooxepine parallel synthesis) (360 wells)
  • DIOX-H (HDAC Structurally-Biased Dioxanes) (7,392 wells)
  • SAD-E (Shikimic Acid-Derived Electrophiles) (4,224 wells)
  • DIOX-2 (1,3-Dioxane) (29216 wells)
  • SDP1 (Serine-derived peptidomimetic) (13728 wells)
  • AML1 (Acyclic and Macrocyclic Lactones) (7,040 wells)
  • SAH1 (Shikimic Acid Derived, Heck Chemistry) (6,336 wells)
  • SpOx1 (Spirooxindole Chemistry) (9,152 wells)
  • Fold1 (Furan Oxidation Library) (3,520 wells)

Libraries in the QC Process

  • SAD2 (Shikimic Acid-Derived) (4,224 wells)

Legacy Libraries (libraries that have been retired)

  • FPK1 (Ferrier/Pauson-Khand DOS library, (S) configuration) (3,520 wells)
  • FPK2 (Ferrier/Pauson-Khand DOS library, (R) configuration) (2,816 wells)
  • GLL1 (Galanthamine-like) (2527 wells)
  • DAP1 (Diels-Alder Polycyclic adducts) (21,120 wells)
  • CycPep2 (Cyclic Peptides, 3- and 4-mer parallel synthesis) (4,928 wells)
  • CLL1 (Carpanone-like) (19,360 wells)
  • DDS1 (9600 wells)
  • SES1 (Ansa-Seco Steroid) (7,744 wells)

DOS Diversity Set

Discrete Collections

These compounds were collected individually from chemists at the Broad Institute and other affiliated institutions.

* = currently not available for screening

  • ICCB1 (190 compounds)
  • ICCB2 (352 compounds)
  • * ICCB3 (352 compounds)
  • ICCB4 (352 compounds)
  • ICCB5 (352 compounds)
  • ICCB6 (352 compounds)
  • CMLD1 (Chemical methodology library development) (332 compounds)

Please also visit the Screening Department's list of Compound Libraries.

[back to top]