March 10th, 2015
Anemia affects nearly one-third of the global population. Much of this burden can be attributed to nutritional deficiencies, infections, and systemic etiologies, such as chronic kidney disease. But genetic disorders of hemoglobin, such as sickle cell disease and thalassemia, are also common causes, particularly among children. Understanding the basic biology of anemia could lead to clinically relevant findings. For this reason Broad associate member Vijay Sankaran and co-author Mitchell Weiss of St. Jude Children’s Research Hospital (Memphis) penned a review article for Nature Medicine that examined recent insights into how red blood cells are produced, the pathogenic mechanisms behind anemia, and a host of associated novel therapies.