Semiconductor-based DNA sequencing of histone modification states.
Nat Commun
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Abstract | The recent development of a semiconductor-based, non-optical DNA sequencing technology promises scalable, low-cost and rapid sequence data production. The technology has previously been applied mainly to genomic sequencing and targeted re-sequencing. Here we demonstrate the utility of Ion Torrent semiconductor-based sequencing for sensitive, efficient and rapid chromatin immunoprecipitation followed by sequencing (ChIP-seq) through the application of sample preparation methods that are optimized for ChIP-seq on the Ion Torrent platform. We leverage this method for epigenetic profiling of tumour tissues. |
Year of Publication | 2013
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Journal | Nat Commun
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Volume | 4
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Pages | 2672
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Date Published | 2013
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ISSN | 2041-1723
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URL | |
DOI | 10.1038/ncomms3672
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PubMed ID | 24157732
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PubMed Central ID | PMC3917140
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Grant list | U54 HG003067 / HG / NHGRI NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
U01 CA1411508 / CA / NCI NIH HHS / United States
F32 CA168253 / CA / NCI NIH HHS / United States
U54HG003067 / HG / NHGRI NIH HHS / United States
DP1OD003958-01 / OD / NIH HHS / United States
R01 CA093947 / CA / NCI NIH HHS / United States
Howard Hughes Medical Institute / United States
P50 HG006193 / HG / NHGRI NIH HHS / United States
1P50HG006193-01 / HG / NHGRI NIH HHS / United States
P50 CA093459 / CA / NCI NIH HHS / United States
U01 CA141508 / CA / NCI NIH HHS / United States
R01 CA93947 / CA / NCI NIH HHS / United States
DP1 OD003958 / OD / NIH HHS / United States
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