Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Am J Hum Genet
Authors
Keywords
Abstract

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p

Year of Publication
2014
Journal
Am J Hum Genet
Volume
94
Issue
3
Pages
349-60
Date Published
2014 Mar 06
ISSN
1537-6605
URL
DOI
10.1016/j.ajhg.2013.12.016
PubMed ID
24560520
PubMed Central ID
PMC3951943
Links
Grant list
SP/08/002/24118 / British Heart Foundation / United Kingdom
G9521010 / Medical Research Council / United Kingdom
PG/09/022/26739 / British Heart Foundation / United Kingdom
G0802432 / Medical Research Council / United Kingdom
FS/11/35/28871 / British Heart Foundation / United Kingdom
UL1 TR000064 / TR / NCATS NIH HHS / United States
U01 GM074492 / GM / NIGMS NIH HHS / United States
R37 AG011099 / AG / NIA NIH HHS / United States
R01 AG021917 / AG / NIA NIH HHS / United States
FS/12/33/29561 / British Heart Foundation / United Kingdom
R01 AG016592 / AG / NIA NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
PG/07/085/23349 / British Heart Foundation / United Kingdom
R01 HL074730 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
FS/14/12/30540 / British Heart Foundation / United Kingdom
FS/12/8/29377 / British Heart Foundation / United Kingdom
P30 DK072488 / DK / NIDDK NIH HHS / United States
MC_UU_12013/1 / Medical Research Council / United Kingdom
090532 / Wellcome Trust / United Kingdom
G0902313 / Medical Research Council / United Kingdom
MR/K006584/1 / Medical Research Council / United Kingdom
MR/K013351/1 / Medical Research Council / United Kingdom
MC_UU_12013/8 / Medical Research Council / United Kingdom