Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.
Authors | |
Keywords | |
Abstract | BACKGROUND: Telomere length is a heritable trait, and short telomere length has been associated with multiple chronic diseases. We investigated the relationship of relative leukocyte telomere length with cardiometabolic risk and performed the first genome-wide association study and meta-analysis to identify variants influencing relative telomere length in a population of Sikhs from South Asia. METHODS AND RESULTS: Our results revealed a significant independent association of shorter relative telomere length with type 2 diabetes mellitus and heart disease. Our discovery genome-wide association study (n=1616) was followed by stage 1 replication of 25 top signals (P CONCLUSIONS: By identification of a novel signal in telomere pathway genes, our study provides new molecular insight into the underlying mechanism that may regulate telomere length and its association with human aging and cardiometabolic pathophysiology. |
Year of Publication | 2014
|
Journal | Circ Cardiovasc Genet
|
Volume | 7
|
Issue | 3
|
Pages | 287-95
|
Date Published | 2014 Jun
|
ISSN | 1942-3268
|
URL | |
DOI | 10.1161/CIRCGENETICS.113.000412
|
PubMed ID | 24795349
|
PubMed Central ID | PMC4106467
|
Links | |
Grant list | RG/08/008/25291 / British Heart Foundation / United Kingdom
PG08/008 / British Heart Foundation / United Kingdom
R01 DK082766 / DK / NIDDK NIH HHS / United States
R01DK082766 / DK / NIDDK NIH HHS / United States
K01 TW006087 / TW / FIC NIH HHS / United States
|