Effect of genetic variants associated with plasma homocysteine levels on stroke risk.

Stroke
Authors
Keywords
Abstract

BACKGROUND AND PURPOSE: Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes.

METHODS: Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs.

RESULTS: One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P

CONCLUSIONS: This study found several potential associations with IS and its subtypes: an association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS.

Year of Publication
2014
Journal
Stroke
Volume
45
Issue
7
Pages
1920-4
Date Published
2014 Jul
ISSN
1524-4628
URL
DOI
10.1161/STROKEAHA.114.005208
PubMed ID
24846872
PubMed Central ID
PMC4083192
Links
Grant list
Medical Research Council / United Kingdom
Department of Health / United Kingdom
P30 DK072488 / DK / NIDDK NIH HHS / United States
Z99 OD999999 / Intramural NIH HHS / United States
Wellcome Trust / United Kingdom