Effect of genetic variants associated with plasma homocysteine levels on stroke risk.
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Abstract | BACKGROUND AND PURPOSE: Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes. METHODS: Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs. RESULTS: One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P CONCLUSIONS: This study found several potential associations with IS and its subtypes: an association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS. |
Year of Publication | 2014
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Journal | Stroke
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Volume | 45
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Issue | 7
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Pages | 1920-4
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Date Published | 2014 Jul
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ISSN | 1524-4628
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URL | |
DOI | 10.1161/STROKEAHA.114.005208
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PubMed ID | 24846872
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PubMed Central ID | PMC4083192
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Grant list | Medical Research Council / United Kingdom
Department of Health / United Kingdom
P30 DK072488 / DK / NIDDK NIH HHS / United States
Z99 OD999999 / Intramural NIH HHS / United States
Wellcome Trust / United Kingdom
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