Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture.
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Abstract | The extent of recent selection in admixed populations is currently an unresolved question. We scanned the genomes of 29,141 African Americans and failed to find any genome-wide-significant deviations in local ancestry, indicating no evidence of selection influencing ancestry after admixture. A recent analysis of data from 1,890 African Americans reported that there was evidence of selection in African Americans after their ancestors left Africa, both before and after admixture. Selection after admixture was reported on the basis of deviations in local ancestry, and selection before admixture was reported on the basis of allele-frequency differences between African Americans and African populations. The local-ancestry deviations reported by the previous study did not replicate in our very large sample, and we show that such deviations were expected purely by chance, given the number of hypotheses tested. We further show that the previous study's conclusion of selection in African Americans before admixture is also subject to doubt. This is because the FST statistics they used were inflated and because true signals of unusual allele-frequency differences between African Americans and African populations would be best explained by selection that occurred in Africa prior to migration to the Americas. |
Year of Publication | 2014
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Journal | Am J Hum Genet
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Volume | 95
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Issue | 4
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Pages | 437-44
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Date Published | 2014 Oct 02
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ISSN | 1537-6605
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URL | |
DOI | 10.1016/j.ajhg.2014.08.011
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PubMed ID | 25242497
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PubMed Central ID | PMC4185117
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Grant list | P30 CA016672 / CA / NCI NIH HHS / United States
R01 GM100233 / GM / NIGMS NIH HHS / United States
UM1 CA164920 / CA / NCI NIH HHS / United States
R01 CA092447 / CA / NCI NIH HHS / United States
R01 HG006399 / HG / NHGRI NIH HHS / United States
T32 GM008692 / GM / NIGMS NIH HHS / United States
K07 CA172294 / CA / NCI NIH HHS / United States
R01 ES011126 / ES / NIEHS NIH HHS / United States
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