Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics.
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Abstract | Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here, we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species. |
Year of Publication | 2015
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Journal | Science
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Volume | 347
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Issue | 6217
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Pages | 1258524
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Date Published | 2015 Jan 02
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ISSN | 1095-9203
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URL | |
DOI | 10.1126/science.1258524
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PubMed ID | 25431491
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PubMed Central ID | PMC4380269
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Links | |
Grant list | R01AI085079 / AI / NIAID NIH HHS / United States
R21 AI099528 / AI / NIAID NIH HHS / United States
G1100339 / Medical Research Council / United Kingdom
Medical Research Council / United Kingdom
R01AI076584 / AI / NIAID NIH HHS / United States
R01AI104956 / AI / NIAID NIH HHS / United States
R21 AI101459 / AI / NIAID NIH HHS / United States
HHSN272200900039C / PHS HHS / United States
T32 GM007757 / GM / NIGMS NIH HHS / United States
R01 AI085079 / AI / NIAID NIH HHS / United States
T32GM007757 / GM / NIGMS NIH HHS / United States
R21AI101459 / AI / NIAID NIH HHS / United States
R01 AI063508 / AI / NIAID NIH HHS / United States
HHSN272200900039C / AI / NIAID NIH HHS / United States
R01 AI076584 / AI / NIAID NIH HHS / United States
R21 AI094289 / AI / NIAID NIH HHS / United States
R21AI094289 / AI / NIAID NIH HHS / United States
R21AI099528 / AI / NIAID NIH HHS / United States
R01 AI104956 / AI / NIAID NIH HHS / United States
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