Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
PLoS Genet
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Abstract | Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P |
Year of Publication | 2015
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Journal | PLoS Genet
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Volume | 11
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Issue | 1
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Pages | e1004876
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Date Published | 2015 Jan
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ISSN | 1553-7404
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URL | |
DOI | 10.1371/journal.pgen.1004876
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PubMed ID | 25625282
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PubMed Central ID | PMC4307976
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Links | |
Grant list | R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
UL1 TR000430 / TR / NCATS NIH HHS / United States
098017 / Wellcome Trust / United Kingdom
DK085524 / DK / NIDDK NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
WT098381 / Wellcome Trust / United Kingdom
095010/Z/10/Z / Wellcome Trust / United Kingdom
K24 DK080140 / DK / NIDDK NIH HHS / United States
090532 / Wellcome Trust / United Kingdom
DK085584 / DK / NIDDK NIH HHS / United States
DK085545 / DK / NIDDK NIH HHS / United States
U01 DK078616 / DK / NIDDK NIH HHS / United States
DK085526 / DK / NIDDK NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
DK085501 / DK / NIDDK NIH HHS / United States
WT090532 / Wellcome Trust / United Kingdom
P30 DK020572 / DK / NIDDK NIH HHS / United States
WT098017 / Wellcome Trust / United Kingdom
095101 / Wellcome Trust / United Kingdom
098381 / Wellcome Trust / United Kingdom
086596/Z/08/Z / Wellcome Trust / United Kingdom
WT064890 / Wellcome Trust / United Kingdom
G0601261 / Medical Research Council / United Kingdom
P30 DK020595 / DK / NIDDK NIH HHS / United States
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