Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

Nat Genet
Authors
Keywords
Abstract

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions, finding major pathways contributing to risk, with some loci shared across immune disorders. To make genetic comparisons across autoimmune disorders as informative as possible, a dense genotyping array, the Immunochip, was developed, from which we identified four new T1D-associated regions (P

Year of Publication
2015
Journal
Nat Genet
Volume
47
Issue
4
Pages
381-6
Date Published
2015 Apr
ISSN
1546-1718
URL
DOI
10.1038/ng.3245
PubMed ID
25751624
PubMed Central ID
PMC4380767
Links
Grant list
100140 / Wellcome Trust / United Kingdom
R01 DK046635 / DK / NIDDK NIH HHS / United States
R01 HG004037 / HG / NHGRI NIH HHS / United States
WT061858/09115 / Wellcome Trust / United Kingdom
DP3 DK085678 / DK / NIDDK NIH HHS / United States
R01 DK096926 / DK / NIDDK NIH HHS / United States
089989 / Wellcome Trust / United Kingdom
DK046635 / DK / NIDDK NIH HHS / United States
076113 / Wellcome Trust / United Kingdom
U01 DK062418 / DK / NIDDK NIH HHS / United States
DK085678 / DK / NIDDK NIH HHS / United States
091157 / Wellcome Trust / United Kingdom